Design of microaerobically inducible miniR1 plasmids.
mLife
; 2(1): 101-104, 2023 Mar.
Article
em En
| MEDLINE
| ID: mdl-38818336
ABSTRACT
Plasmid DNA manufacture is an essential step to produce gene therapy agents and next-generation vaccines. However, little attention has been paid toward developing alternative replicons that can be coupled with large-scale production conditions. Our results demonstrate that the miniR1 replicon can be efficiently induced by oxygen limitation when a copy of the regulatory protein RepA under control of a microaerobic promoter is used. The results are potentially attractive for industrial applications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
MLife
Ano de publicação:
2023
Tipo de documento:
Article