Changes in M6A methylation: A key factor in the vicious cycle of flora -gut aging.
Ageing Res Rev
; 98: 102351, 2024 07.
Article
em En
| MEDLINE
| ID: mdl-38820855
ABSTRACT
The aging process significantly impacts the gastrointestinal tract and various bodily systems, exacerbating age-related diseases. Research suggests a correlation between an imbalance in intestinal flora and gut aging, yet the precise mechanism remains incompletely elucidated. Epigenetic modifications, particularly m6A methylation, play a pivotal role in driving aging and are closely associated with gut aging. Maintaining a healthy balance of intestinal microbes is contingent upon m6A methylation, which is believed to be crucial in the vicious cycle of gut aging and intestinal flora. This article highlights the importance of m6A methylation in the nexus between gut aging and flora. It proposes the potential for targeted m6A methylation to break the vicious cycle of gut aging and flora imbalance, offering novel perspectives on attenuating or reversing gut aging.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Microbioma Gastrointestinal
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ageing Res Rev
Ano de publicação:
2024
Tipo de documento:
Article