The m6A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism.
Exp Mol Med
; 56(6): 1373-1387, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38825643
ABSTRACT
N6-adenosine methylation (m6A) is critical for controlling cancer cell growth and tumorigenesis. However, the function and detailed mechanism of how m6A methyltransferases modulate m6A levels on specific targets remain unknown. In the current study, we identified significantly elevated levels of RBM15, an m6A writer, in basal-like breast cancer (BC) patients compared to nonbasal-like BC patients and linked this increase to worse clinical outcomes. Gene expression profiling revealed correlations between RBM15 and serine and glycine metabolic genes, including PHGDH, PSAT1, PSPH, and SHMT2. RBM15 influences m6A levels and, specifically, the m6A levels of serine and glycine metabolic genes via direct binding to target RNA. The effects of RBM15 on cell growth were largely dependent on serine and glycine metabolism. Thus, RBM15 coordinates cancer cell growth through altered serine and glycine metabolism, suggesting that RBM15 is a new therapeutic target in BC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Serina
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Regulação Neoplásica da Expressão Gênica
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Proteínas de Ligação a RNA
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Proliferação de Células
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Neoplasias de Mama Triplo Negativas
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Glicina
Limite:
Female
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Humans
Idioma:
En
Revista:
Exp Mol Med
Ano de publicação:
2024
Tipo de documento:
Article