IgA multiple myeloma-associated mediastinal spinal plasmacytoma presenting as spinal cord compression.
BMJ Case Rep
; 17(6)2024 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-38844357
ABSTRACT
Multiple myeloma associated with extramedullary plasmacytoma at initial presentation is rare. We describe a case of a man in his 30s who initially presented with symptoms of spinal cord compression. Further imaging revealed a mediastinal tumour, with a biopsy confirming plasmacytoma. Immunofixation revealed IgA lambda paraprotein. Bone marrow biopsy demonstrated atypical T-cell cytotoxic proliferation and trilineage hypoplasia. The patient was diagnosed with extramedullary plasmacytoma with active IgA multiple myeloma. The patient received mediastinal radiation to the tumour, followed by anti-myeloma therapy. This diagnosis is critical as managing a solitary plasmacytoma drastically differs from an extramedullary plasmacytoma with active multiple myeloma.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmocitoma
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Compressão da Medula Espinal
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Imunoglobulina A
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Neoplasias do Mediastino
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Mieloma Múltiplo
Limite:
Adult
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Humans
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Male
Idioma:
En
Revista:
BMJ Case Rep
Ano de publicação:
2024
Tipo de documento:
Article