Antibody status at delivery and pregnancy outcomes during the first Danish COVID-19 wave.
Dan Med J
; 71(6)2024 05 01.
Article
em En
| MEDLINE
| ID: mdl-38847410
ABSTRACT
INTRODUCTION:
We aimed to investigate the prevalence of SARS-CoV-2 infection and SARS-CoV-2 antibodies in parturient women and their newborns during the first Danish COVID-19 wave and to identify associations with maternal background characteristics, self-reported symptoms, and pregnancy outcomes.METHODS:
In a single-centre, prospective cohort study from Denmark, we invited 1,883 women with singleton pregnancies giving live birth from 25 May 2020 to 2 November 2020. Hereof, 953 (50.6%) women were included. Nasopharyngeal swabs, maternal and umbilical cord blood samples, and questionnaires were collected. Medical records were available for participants and non-participants.RESULTS:
SARS-CoV-2 antibodies were found in 1.3% of the women. All newborns of seropositive women had SARS-CoV-2 antibodies in cord blood. No association was found between SARS-CoV-2 antibodies and pregnancy outcomes. Self-reported loss of smell correlated with seropositivity (p less-than 0.001). No women were hospitalised due to COVID-19 during pregnancy or had a positive nasopharyngeal swab intrapartum.CONCLUSIONS:
The prevalence of COVID-19 in pregnancy was low during the first wave. Maternal SARS-CoV-2 antibodies were associated with antibodies in cord blood, loss of smell and positive SARS-CoV-2 swab during pregnancy, but not with any adverse pregnancy outcomes.FUNDING:
Ferring Pharmaceuticals funded part of the study. TRIAL REGISTRATION The study was approved by the Regional Committee on Health Research Ethics (H-20028002) and the Danish Data Protection Agency (P-2020-264).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Resultado da Gravidez
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SARS-CoV-2
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COVID-19
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Anticorpos Antivirais
Limite:
Adult
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Female
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Humans
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Newborn
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Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Dan Med J
/
Danish medical journa
/
Danish medical journal
Ano de publicação:
2024
Tipo de documento:
Article