HPV integration and cervical cancer: a failed evolutionary viral trait.
Trends Mol Med
; 30(9): 890-902, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38853085
ABSTRACT
Countless efforts have been made to eradicate cervical cancer worldwide, including improving disease screening and human papillomavirus (HPV) vaccination programs. Nevertheless, cervical cancer still claims the lives of more than 300 000 women every year. Persistent infections with high-risk HPV genotypes 16 and 18 are the main cause of cancer and may result in HPV integration into the host genome. The central dogma is that HPV integration is an important step in oncogenesis, but in fact, it impedes the virus from replicating and spreading. HPV causing cervical cancer can therefore be perceived as a failed evolutionary viral trait. Here we outline the occurrence and mechanisms of HPV integration and how this process results in oncogenic transformation.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo do Útero
/
Integração Viral
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Infecções por Papillomavirus
Limite:
Female
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Humans
Idioma:
En
Revista:
Trends Mol Med
Ano de publicação:
2024
Tipo de documento:
Article