Building the brain mosaic: an expanded view.
Trends Genet
; 40(9): 747-756, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38853120
ABSTRACT
The complexity of the brain is closely tied to its nature as a genetic mosaic, wherein each cell is distinguished by a unique constellation of somatic variants that contribute to functional and phenotypic diversity. Postzygotic variation arising during neurogenesis is recognized as a key contributor to brain mosaicism; however, recent advances have broadened our understanding to include sources of neural genomic diversity that develop throughout the entire lifespan, from embryogenesis through aging. Moving beyond the traditional confines of neurodevelopment, in this review, we delve into the complex mechanisms that enable various origins of brain mosaicism.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Mosaicismo
Limite:
Animals
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Humans
Idioma:
En
Revista:
Trends Genet
Ano de publicação:
2024
Tipo de documento:
Article