Development of an organ-on-chip model for the detection of volatile organic compounds as potential biomarkers of tumour progression.
Biofabrication
; 16(4)2024 Jul 04.
Article
em En
| MEDLINE
| ID: mdl-38866002
ABSTRACT
Early detection of tumours remains a significant challenge due to their invasive nature and the limitations of current monitoring techniques. Liquid biopsies have emerged as a minimally invasive diagnostic approach, wherein volatile organic compounds (VOCs) show potential as compelling candidates. However, distinguishing tumour-specific VOCs is difficult due to the presence of gases from non-tumour tissues and environmental factors. Therefore, it is essential to develop preclinical models that accurately mimic the intricate tumour microenvironment to induce cellular metabolic changes and secretion of tumour-associated VOCs. In this study, a microfluidic device was used to recreate the ischaemic environment within solid tumours for the detection of tumour-derived VOCs. The system represents a significant advance in understanding the role of VOCs as biomarkers for early tumour detection and holds the potential to improve patient prognosis; particularly for inaccessible and rapidly progressing tumours such as glioblastoma.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Progressão da Doença
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Compostos Orgânicos Voláteis
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Dispositivos Lab-On-A-Chip
Limite:
Humans
Idioma:
En
Revista:
Biofabrication
Ano de publicação:
2024
Tipo de documento:
Article