Peripheral cytokine interleukin-10 alleviates perihematomal edema after intracerebral hemorrhage via interleukin-10 receptor/JAK1/STAT3 signaling.
CNS Neurosci Ther
; 30(6): e14796, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38867395
ABSTRACT
AIMS:
The extent of perihematomal edema following intracerebral hemorrhage (ICH) significantly impacts patient prognosis, and disruption of the blood-brain barrier (BBB) exacerbates perihematomal edema. However, the role of peripheral IL-10 in mitigating BBB disruption through pathways that link peripheral and central nervous system signals remains poorly understood.METHODS:
Recombinant IL-10 was administered to ICH model mice via caudal vein injection, an IL-10-inhibiting adeno-associated virus and an IL-10 receptor knockout plasmid were delivered intraventricularly, and neurobehavioral deficits, perihematomal edema, BBB disruption, and the expression of JAK1 and STAT3 were evaluated.RESULTS:
Our study demonstrated that the peripheral cytokine IL-10 mitigated BBB breakdown, perihematomal edema, and neurobehavioral deficits after ICH and that IL-10 deficiency reversed these effects, likely through the IL-10R/JAK1/STAT3 signaling pathway.CONCLUSIONS:
Peripheral IL-10 has the potential to reduce BBB damage and perihematomal edema following ICH and improve patient prognosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Edema Encefálico
/
Transdução de Sinais
/
Hemorragia Cerebral
/
Interleucina-10
/
Fator de Transcrição STAT3
/
Janus Quinase 1
/
Receptores de Interleucina-10
Limite:
Animals
Idioma:
En
Revista:
CNS Neurosci Ther
Ano de publicação:
2024
Tipo de documento:
Article