Macrophages on the wrinkle: Exploring microscale interactions with substrate topography.
Biophys Rev (Melville)
; 5(2): 022001, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38868521
ABSTRACT
Macrophages play pivotal roles in the immune response, participating in both inflammatory and pro-healing processes. Like other cells, macrophages continually survey their microenvironment through mechanosensing, adapting their intracellular organization in response to mechanical signals. In this study, we elucidate how macrophages perceive the topographical cues of wrinkled surfaces through actin-based structures, which align with the main pattern direction, thus modulating cell cytoskeletal dynamics. Given that such alterations may regulate mechanosensitive gene expression programs, exploring cellular responses to biomaterial design becomes crucial for developing biomaterials that mitigate adverse reactions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Biophys Rev (Melville)
Ano de publicação:
2024
Tipo de documento:
Article