Kinetic Resolution of N-Allylic Pyrazoles via Photoexcited Chiral Copper Complex-Catalyzed Alkene E â Z Isomerization.
Org Lett
; 26(25): 5232-5236, 2024 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-38869179
ABSTRACT
Herein, we present an efficient and practical kinetic resolution (KR) of racemic allylic pyrazoles utilizing photoexcited chiral-copper-complex-mediated alkene E â Z isomerization. This method enables the synthesis of both enantioenriched E- and Z-allylic pyrazoles, achieving enantiomeric excesses (e.e.) of up to 97% and selectivity factors (S factors) as high as 217. Remarkably, the method's ability to furnish allylic pyrazoles with the Z-configuration, which is notably arduous to obtain under thermodynamic control, underscores the transformative potential of this synthetic protocol.
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01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2024
Tipo de documento:
Article