WhiB-like proteins: Diversity of structure, function and mechanism.
Biochim Biophys Acta Mol Cell Res
; 1871(7): 119787, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-38879133
ABSTRACT
The WhiB-Like (Wbl) proteins are a large family of iron-sulfur (Fe-S) cluster-containing transcription factors exclusively found in the phylum Actinobacteria, including the notable genera like Mycobacteria, Streptomycetes and Corynebacteria. These proteins play pivotal roles in diverse biological processes, such as cell development, redox stress response and antibiotic resistance. Members of the Wbl family exhibit remarkable diversity in their sequences, structures and functions, attracting great attention since their first discovery. This review highlights the most recent breakthroughs in understanding the structural and mechanistic aspects of Wbl-dependent transcriptional regulation.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Fatores de Transcrição
/
Proteínas Ferro-Enxofre
Idioma:
En
Revista:
Biochim Biophys Acta Mol Cell Res
Ano de publicação:
2024
Tipo de documento:
Article