Rat strain differences in seizure frequency and hilar neuron loss after systemic treatment with pilocarpine.
Epilepsy Res
; 204: 107384, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38879905
ABSTRACT
At least 3 months after systemic treatment with pilocarpine to induce status epilepticus, Long-Evans and Sprague-Dawley rats were video-EEG monitored for seizures continuously for 1 month. Rats were then perfused, hippocampi were processed for Nissl staining, and hilar neurons were quantified. Seizure frequency in Long-Evans rats was 1/10th of that in Sprague-Dawley rats, and more variable. Hilar neuron loss was also less severe in Long-Evans rats. However, there was no correlation between hilar neuron loss and seizure frequency in either strain. The low and variable seizure frequency suggests limited usefulness of pilocarpine-treated Long-Evans rats for some epilepsy experiments.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pilocarpina
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Convulsões
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Ratos Sprague-Dawley
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Ratos Long-Evans
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Eletroencefalografia
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Neurônios
Limite:
Animals
Idioma:
En
Revista:
Epilepsy Res
Ano de publicação:
2024
Tipo de documento:
Article