Fertility and Pregnancy-Related Issues in Young BRCA Carriers With Breast Cancer.
Breast Cancer (Auckl)
; 18: 11782234241261429, 2024.
Article
em En
| MEDLINE
| ID: mdl-38882447
ABSTRACT
Approximately 10% to 15% of breast cancer cases in young women are diagnosed in patients harbouring germline (g) pathogenic or likely pathogenic variants (PVs) in the BReast CAncer 1 (BRCA1) or BReast CAncer 2 (BRCA2) genes. Preclinical and clinical studies showed a potential negative effect of germline BRCA1/2 (gBRCA1/2) PVs on ovarian reserve and reproductive potential, even before starting anticancer therapies. The aim of this article is to summarize the current literature on the fertility potential of young gBRCA1/2 PVs carriers with breast cancer and the risk of gonadotoxicity associated with anticancer treatments. Moreover, we describe the available evidence on the efficacy of fertility preservation techniques in young gBRCA1/2 PVs carriers and the safety data on having a pregnancy after breast cancer treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Breast Cancer (Auckl)
Ano de publicação:
2024
Tipo de documento:
Article