Differential cortical layer engagement during seizure initiation and spread in humans.
Nat Commun
; 15(1): 5153, 2024 Jun 17.
Article
em En
| MEDLINE
| ID: mdl-38886376
ABSTRACT
Despite decades of research, we still do not understand how spontaneous human seizures start and spread - especially at the level of neuronal microcircuits. In this study, we used laminar arrays of micro-electrodes to simultaneously record the local field potentials and multi-unit neural activities across the six layers of the neocortex during focal seizures in humans. We found that, within the ictal onset zone, the discharges generated during a seizure consisted of current sinks and sources only within the infra-granular and granular layers. Outside of the seizure onset zone, ictal discharges reflected current flow in the supra-granular layers. Interestingly, these patterns of current flow evolved during the course of the seizure - especially outside the seizure onset zone where superficial sinks and sources extended into the deeper layers. Based on these observations, a framework describing cortical-cortical dynamics of seizures is proposed with implications for seizure localization, surgical targeting, and neuromodulation techniques to block the generation and propagation of seizures.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Neocórtex
/
Eletroencefalografia
Limite:
Adult
/
Female
/
Humans
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Male
Idioma:
En
Revista:
Nat Commun
Ano de publicação:
2024
Tipo de documento:
Article