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Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis.
Fererberger, Tanja; Buechler, Christa; Kandulski, Arne; Elger, Tanja; Loibl, Johanna; Schmid, Stephan; Sommersberger, Stefanie; Gunawan, Stefan; Zundler, Sebastian; Huss, Muriel; Bettenworth, Dominik; Kempa, Sally; Weidlich, Simon; Föh, Bandik; Huang, Xinyu; Grzegorzek, Marcin; Derer-Petersen, Stefanie; Günther, Ulrich L; Marquardt, Jens U; Kunst, Claudia; Gülow, Karsten; Müller, Martina; Sina, Christian; Schmelter, Franziska; Tews, Hauke C.
Afiliação
  • Fererberger T; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Buechler C; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Kandulski A; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Elger T; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Loibl J; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Schmid S; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Sommersberger S; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Gunawan S; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Zundler S; Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany.
  • Huss M; Deutsches Zentrum Immuntherapie, University Hospital Erlangen, Erlangen, Germany.
  • Bettenworth D; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Kempa S; Department of Medicine B - Gastroenterology and Hepatology, University Hospital Münster, Münster, Germany.
  • Weidlich S; Practice for Internal Medicine, Münster, Germany.
  • Föh B; Department for Plastic, Hand, and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
  • Huang X; Department of Internal Medicine II, School of Medicine and Health, University Hospital Rechts der Isar, Technical University of Munich, Munich, Germany.
  • Grzegorzek M; Institute of Nutritional Medicine, University Medical Center Schleswig-Holstein, Lübeck, Germany.
  • Derer-Petersen S; Department of Medicine I, University Medical Center Schleswig-Holstein, Lübeck, Germany.
  • Günther UL; Institute of Medical Informatics, University of Lübeck, Lübeck, Germany.
  • Marquardt JU; Institute of Medical Informatics, University of Lübeck, Lübeck, Germany.
  • Kunst C; Institute of Nutritional Medicine, University Medical Center Schleswig-Holstein, Lübeck, Germany.
  • Gülow K; Institute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany.
  • Müller M; Department of Medicine I, University Medical Center Schleswig-Holstein, Lübeck, Germany.
  • Sina C; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Schmelter F; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
  • Tews HC; Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany.
Front Med (Lausanne) ; 11: 1334865, 2024.
Article em En | MEDLINE | ID: mdl-38895187
ABSTRACT
Intoduction Identification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification.

Methods:

Nuclear magnetic resonance (NMR) spectroscopy revealed an altered metabolome and lipidome of 33 patients with PSC [24 patients with inflammatory bowel disease (IBD) and 9 patients without IBD] compared with 40 age-, sex-, and body mass index (BMI)-matched healthy controls (HC) as well as 64 patients with IBD and other extraintestinal manifestations (EIM) but without PSC.

Results:

In particular, higher concentrations of pyruvic acid and several lipoprotein subfractions were measured in PSC in comparison to HC. Of clinical relevance, a specific amino acid and lipid profile was determined in PSC compared with IBD and other EIM.

Discussion:

These results have the potential to improve diagnosis by differentiating PSC patients from HC and those with IBD and EIM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Med (Lausanne) Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Med (Lausanne) Ano de publicação: 2024 Tipo de documento: Article