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Cell-type-specific cholinergic control of granular retrosplenial cortex with implications for angular velocity coding across brain states.
Jedrasiak-Cape, Izabela; Rybicki-Kler, Chloe; Brooks, Isla; Ghosh, Megha; Brennan, Ellen K W; Kailasa, Sameer; Ekins, Tyler G; Rupp, Alan; Ahmed, Omar J.
Afiliação
  • Jedrasiak-Cape I; Dept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
  • Rybicki-Kler C; Dept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
  • Brooks I; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109.
  • Ghosh M; Dept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
  • Brennan EKW; Dept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
  • Kailasa S; Dept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
  • Ekins TG; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109.
  • Rupp A; Dept. of Mathematics, University of Michigan, Ann Arbor, MI 48109.
  • Ahmed OJ; Dept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
bioRxiv ; 2024 Jun 06.
Article em En | MEDLINE | ID: mdl-38895393
ABSTRACT
Cholinergic receptor activation enables the persistent firing of cortical pyramidal neurons, providing a key cellular basis for theories of spatial navigation involving working memory, path integration, and head direction encoding. The granular retrosplenial cortex (RSG) is important for spatially-guided behaviors, but how acetylcholine impacts RSG neurons is unknown. Here, we show that a transcriptomically, morphologically, and biophysically distinct RSG cell-type - the low-rheobase (LR) neuron - has a very distinct expression profile of cholinergic muscarinic receptors compared to all other neighboring excitatory neuronal subtypes. LR neurons do not fire persistently in response to cholinergic agonists, in stark contrast to all other principal neuronal subtypes examined within the RSG and across midline cortex. This lack of persistence allows LR neuron models to rapidly compute angular head velocity (AHV), independent of cholinergic changes seen during navigation. Thus, LR neurons can consistently compute AHV across brain states, highlighting the specialized RSG neural codes supporting navigation.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2024 Tipo de documento: Article