Anticancer perspectives of monocarbonyl analogs of curcumin: A decade (2014-2024) review.

Nagargoje, Amol A; Deshmukh, Tejshri R; Shaikh, Mubarak H; Khedkar, Vijay M; Shingate, Bapurao B

Nagargoje, Amol A; Deshmukh, Tejshri R; Shaikh, Mubarak H; Khedkar, Vijay M; Shingate, Bapurao B.

Afiliação

Nagargoje AA; Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Chhatrapati Sambhajinagar (Aurangabad), Maharashtra, India.
Deshmukh TR; Department of Chemistry, Khopoli Municipal Council College, Khopoli, Maharashtra, India.
Shaikh MH; Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Chhatrapati Sambhajinagar (Aurangabad), Maharashtra, India.
Khedkar VM; Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Chhatrapati Sambhajinagar (Aurangabad), Maharashtra, India.
Shingate BB; Department of Chemistry, Radhabai Kale Mahila Mahavidyalaya, Ahmednagar, Maharashtra, India.

Arch Pharm (Weinheim) ; 357(9): e2400197, 2024 Sep.

Article em En | MEDLINE | ID: mdl-38895952

ABSTRACT

ABSTRACT

Monocarbonyl analogs of curcumin (MACs) represent structurally modified versions of curcumin. The existing literature indicates that MACs exhibit enhanced anticancer properties compared with curcumin. Numerous research articles in recent years have emphasized the significance of MACs as effective anticancer agents. This review focuses on the latest advances in the anticancer potential of MACs, from 2014 to 2024, including discussions on their mechanism of action, structure-activity relationship (SAR), and in silico molecular docking studies.

Assuntos

Antineoplásicos; Curcumina; Simulação de Acoplamento Molecular; Curcumina/farmacologia; Curcumina/química; Curcumina/síntese química; Curcumina/análogos & derivados; Humanos; Relação Estrutura-Atividade; Antineoplásicos/farmacologia; Antineoplásicos/química; Antineoplásicos/síntese química; Neoplasias/tratamento farmacológico; Animais; Estrutura Molecular

Palavras-chave

anticancer activity; curcumin; molecular docking study; monocarbonyl analogs of curcumin; structureactivity relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Curcumina / Simulação de Acoplamento Molecular / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Arch Pharm (Weinheim) Ano de publicação: 2024 Tipo de documento: Article

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