Electrochemical Bioconjugation of Tryptophan Residues: A Strategy for Peptide Modification.
Org Lett
; 26(26): 5447-5452, 2024 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-38896796
ABSTRACT
Interest in electrocatalytic bioconjugation reactions has surged, particularly for modifying tryptophan and tyrosine residues in proteins. We used a cost-effective graphite felt electrode and low-current methodology to achieve selective bioconjugation of tryptophan with thiophenols, yielding up to 92%. This method exclusively labeled tryptophan residues and incorporated fluorinated tryptophan for NMR analysis. Eight polypeptides, including lanreotide and leuprorelin, were effectively coupled, demonstrating the method's versatility and potential for novel diagnostic and therapeutic agents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Triptofano
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2024
Tipo de documento:
Article