Preliminary analysis of the efficacy of Mohs micrographic surgery combined with photodynamic therapy in a case of noninvasive extramammary Paget's disease.
J Dermatolog Treat
; 35(1): 2368066, 2024 Dec.
Article
em En
| MEDLINE
| ID: mdl-38897607
ABSTRACT
PURPOSE:
To evaluate the efficacy of Mohs micrographic surgery (MMS) combined with photodynamic therapy (PDT) in treating non-invasive extramammary Paget's disease (EMPD). MATERIALS ANDMETHODS:
A 77-year-old male patient with non-invasive EMPD was treated with MMS followed by PDT. Preoperative fluorescence localization using 5-aminolevulinic acid (ALA) was performed to determine the surgical scope. MMS was conducted under lumbar anesthesia with intraoperative frozen-section pathology. Postoperative PDT was administered weekly for three sessions.RESULTS:
The patient achieved negative surgical margins after two rounds of intraoperative pathology. Postoperative follow-up over two years showed no recurrence, and the patient did not experience significant adverse reactions.CONCLUSION:
The combination of MMS and PDT was effective in treating non-invasive EMPD, demonstrating favorable clinical outcomes and no recurrence over the two-year follow-up period.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
/
Neoplasias Cutâneas
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Cirurgia de Mohs
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Fármacos Fotossensibilizantes
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Doença de Paget Extramamária
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Ácido Aminolevulínico
Limite:
Aged
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Humans
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Male
Idioma:
En
Revista:
J Dermatolog Treat
Ano de publicação:
2024
Tipo de documento:
Article