Population Attributable Fraction of Total Stroke Associated with Modifiable Risk Factors in the United States.
Am J Epidemiol
; 2024 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-38897982
ABSTRACT
Stroke is a leading cause of death in the United States across all race/ethnicity and sex groups, though disparities exist. We investigated the potential for primary prevention of total first stroke for Americans aged 20 and older, stratified by sex and race/ethnicity. Specifically, we calculated population attributable fractions (PAF) of first stroke for 7 potentially modifiable risk factors smoking, physical inactivity, poor diet, obesity, hypertension, diabetes, and atrial fibrillation. PAFs are a function of (1) the relative risk of first stroke for people with the exposure and (2) the prevalence of the risk factor in the population. Relative risks came from recent meta-analyses and sex-race/ethnicity-specific prevalence estimates came from the 2015-2018 NHANES or Multi-Ethnic Study of Atherosclerosis (for atrial fibrillation only). Approximately 1/3 (35.7% [CI 21.6%-49.0%]) for women, 32.7% [CI 19.2%-45.1%] for men) of strokes were attributable to the 7 risk factors we considered. A 20% proportional reduction in stroke risk factors would result in approximately 37,000 fewer strokes annually in the United States. The estimated PAF was highest for non-Hispanic Black women (39.3% [CI 24.8%-52.3%]) and lowest for non-Hispanic Asian men (25.5% [CI 14.6%-36.2%]). For most groups, obesity and hypertension were the largest contributors to stroke rates.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Am J Epidemiol
Ano de publicação:
2024
Tipo de documento:
Article