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1-Norm waveform analysis for MR elastography-based quantification of inhomogeneity: Effects of the freeze-thaw cycle and Alzheimer's disease.
Palnitkar, Harish; Reiter, Rolf; Majumdar, Shreyan; Crutison, Joseph; Lin, Shujun; Royston, Thomas J; Klatt, Dieter.
Afiliação
  • Palnitkar H; Department of Mechanical and Industrial Engineering, University of Illinois Chicago, Chicago, IL, 60607, United States; Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, United States. Electronic address: palnitkar.harishravindra@mayo.edu.
  • Reiter R; Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charit
  • Majumdar S; Richard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, 830 South Wood Street, Chicago, IL, 60612, United States. Electronic address: majumdar.shreyan@gmail.com.
  • Crutison J; Richard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, 830 South Wood Street, Chicago, IL, 60612, United States. Electronic address: jcruti2@uic.edu.
  • Lin S; Richard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, 830 South Wood Street, Chicago, IL, 60612, United States. Electronic address: slin78@uic.edu.
  • Royston TJ; Richard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, 830 South Wood Street, Chicago, IL, 60612, United States. Electronic address: troyston@uic.edu.
  • Klatt D; Richard and Loan Hill Department of Biomedical Engineering, University of Illinois Chicago, 830 South Wood Street, Chicago, IL, 60612, United States. Electronic address: dklatt@uic.edu.
J Mech Behav Biomed Mater ; 157: 106636, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38908327
ABSTRACT

BACKGROUND:

Despite its success in the mechanical characterization of biological tissues, magnetic resonance elastography (MRE) uses ill-posed wave inversions to estimate tissue stiffness. 1-Norm has been recently introduced as a mathematical measure for the scattering of mechanical waves due to inhomogeneities based on an analysis of the delineated contours of wave displacement.

PURPOSE:

To investigate 1-Norm as an MRE-based quantitative biomarker of mechanical inhomogeneities arising from microscopic structural tissue alterations caused by the freeze-thaw cycle (FTC) or Alzheimer's disease (AD).

METHODS:

In this proof-of-concept study, we prospectively investigated excised porcine kidney (n = 6), liver (n = 6), and muscle (n = 6) before vs. after the FTC at 500-2000 Hz and excised murine brain of healthy controls (n = 3) vs. 5xFAD species with AD (n = 3) at 1200-1800 Hz using 0.5 T tabletop MRE. 1-Norm analysis was compared with conventional wave inversion.

RESULTS:

While the FTC reduced both stiffness and inhomogeneity in kidney, liver, and muscle tissue, AD led to lower brain stiffness but more pronounced mechanical inhomogeneity.

CONCLUSION:

Our preliminary results show that 1-Norm is sensitive to tissue mechanical inhomogeneity due to FTC and AD without relying on ill-posed wave inversion techniques. 1-Norm has the potential to be used as an MRE-based diagnostic biomarker independent of stiffness to characterize abnormal conditions that involve changes in tissue mechanical inhomogeneity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas de Imagem por Elasticidade / Doença de Alzheimer / Congelamento Limite: Animals Idioma: En Revista: J Mech Behav Biomed Mater Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas de Imagem por Elasticidade / Doença de Alzheimer / Congelamento Limite: Animals Idioma: En Revista: J Mech Behav Biomed Mater Ano de publicação: 2024 Tipo de documento: Article