Chloramphenicol treatment revisited - demographics, clinical characteristics, and outcomes of hospitalized patients.
Eur J Clin Microbiol Infect Dis
; 43(8): 1667-1671, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38913228
ABSTRACT
Limited literature exists on chloramphenicol's clinical use. In this retrospective, single-center case-series, we examined 183 chloramphenicol-treated and 81 piperacillin-tazobactam-treated medical patients. Chloramphenicol recipients were older, more debilitated, cognitively impaired, and penicillin allergic, while increased need for inotropics, higher leukocyte count, and higher creatinine levels were notable in the piperacillin-tazobactam group. Pneumonia was the most common indication, with no mortality difference between groups. While acknowledging its antimicrobial activity and potential benefit in specific conditions such as pneumonia, further clinical studies are needed to assess the role of chloramphenicol in the setting where other alternatives are available.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cloranfenicol
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Antibacterianos
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Clin Microbiol Infect Dis
/
Eur. j. clin. microbiol. infect. dis
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European journal of clinical microbiology and infectious diseases
Ano de publicação:
2024
Tipo de documento:
Article