EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma.
Cell Mol Life Sci
; 81(1): 278, 2024 Jun 25.
Article
em En
| MEDLINE
| ID: mdl-38916835
ABSTRACT
Ephrin receptor A2 (EphA2), a member of the Ephrin receptor family, is closely related to the progression of oral squamous cell carcinoma (OSCC). Cancer stem cells (CSCs) play essential roles in OSCC development and occurrence. The underlying mechanisms between EphA2 and CSCs, however, are not yet fully understood. Here, we found that EphA2 was overexpressed in OSCC tissues and was associated with poor prognosis. Knockdown of EphA2 dampened the CSC phenotype and the tumour-initiating frequency of OSCC cells. Crucially, the effects of EphA2 on the CSC phenotype relied on KLF4, a key transcription factor for CSCs. Mechanistically, EphA2 activated the ERK signalling pathway, promoting the nuclear translocation of YAP. Subsequently, YAP was bound to TEAD3, leading to the transcription of KLF4. Overall, our findings revealed that EphA2 can enhance the stemness of OSCC cells, and this study identified the EphA2/KLF4 axis as a potential target for treating OSCC.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
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Neoplasias Bucais
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Carcinoma de Células Escamosas
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Receptor EphA2
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Fatores de Transcrição Kruppel-Like
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Fator 4 Semelhante a Kruppel
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Cell Mol Life Sci
Ano de publicação:
2024
Tipo de documento:
Article