New Cyclic Pentapeptides from the Mangrove-Derived Aspergillus fumigatus GXIMD 03099.
Mar Drugs
; 22(6)2024 Jun 16.
Article
em En
| MEDLINE
| ID: mdl-38921593
ABSTRACT
Four new cyclic pentapeptides, avellanins D-G (1-4), together with four known compounds (5-8), were isolated from a mangrove-derived Aspergillus fumigatus GXIMD 03099 fungus from Acanthus ilicifolius L. Their structures were elucidated by analysis of HRESIMS, NMR, and ESI-MS/MS data. Their absolute configurations were determined by X-ray diffraction analysis and Marfey's method. Compounds 1-8 were screened for insecticidal and antibacterial activities. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with an LC50 value of 86.6 µM; compound 4 had weak activity against Vibrio harveyi with an MIC value of 5.85 µM.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
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Aspergillus fumigatus
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Testes de Sensibilidade Microbiana
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Inseticidas
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Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
Mar Drugs
Ano de publicação:
2024
Tipo de documento:
Article