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Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk.
Corradi, Chiara; Lencioni, Giulia; Felici, Alessio; Rizzato, Cosmeri; Gentiluomo, Manuel; Ermini, Stefano; Archibugi, Livia; Mickevicius, Antanas; Lucchesi, Maurizio; Malecka-Wojciesko, Ewa; Basso, Daniela; Arcidiacono, Paolo Giorgio; Petrone, Maria Chiara; Carrara, Silvia; Götz, Mara; Bunduc, Stefania; Holleczek, Bernd; Aoki, Mateus Nóbrega; Uzunoglu, Faik G; Zanette, Dalila Lucíola; Mambrini, Andrea; Jamroziak, Krzysztof; Oliverius, Martin; Lovecek, Martin; Cavestro, Giulia Martina; Milanetto, Anna Caterina; Peduzzi, Giulia; Duchonova, Beatrice Mohelnikova; Izbicki, Jakob R; Zalinkevicius, Rimantas; Hlavac, Viktor; van Eijck, Casper H J; Brenner, Hermann; Vanella, Giuseppe; Vokacova, Klara; Soucek, Pavel; Tavano, Francesca; Perri, Francesco; Capurso, Gabriele; Hussein, Tamás; Kiudelis, Mindaugas; Kupcinskas, Juozas; Busch, Olivier R; Morelli, Luca; Theodoropoulos, George E; Testoni, Sabrina Gloria Giulia; Adamonis, Kestutis; Neoptolemos, John P; Gazouli, Maria; Pasquali, Claudio.
Afiliação
  • Corradi C; Department of Biology, University of Pisa, Pisa, Italy.
  • Lencioni G; Department of Biology, University of Pisa, Pisa, Italy.
  • Felici A; Department of Biology, University of Pisa, Pisa, Italy.
  • Rizzato C; Department of Biology, University of Pisa, Pisa, Italy.
  • Gentiluomo M; Department of Biology, University of Pisa, Pisa, Italy.
  • Ermini S; Blood Transfusion Service, Azienda Ospedaliera-Universitaria Meyer, Children's Hospital, Florence, Italy.
  • Archibugi L; Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy.
  • Mickevicius A; Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
  • Lucchesi M; Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Malecka-Wojciesko E; Oncology of Massa Carrara, Oncological Department, Azienda USL Toscana Nord Ovest, Carrara, Italy.
  • Basso D; Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
  • Arcidiacono PG; Laboratory Medicine, Department DIMED, University of Padova, Padua, Italy.
  • Petrone MC; Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy.
  • Carrara S; Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy.
  • Götz M; Endoscoopic Unit, Gastroenterology Department, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
  • Bunduc S; Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
  • Holleczek B; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
  • Aoki MN; Digestive Diseases and Liver Transplantation Center, Fundeni Clinical Institute, Bucharest, Romania.
  • Uzunoglu FG; Center for Translational Medicine, Semmelweis University, Budapest, Hungary.
  • Zanette DL; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
  • Mambrini A; Saarland Cancer Registry, Saarbrücken, Germany.
  • Jamroziak K; Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Parana, Brazil.
  • Oliverius M; Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
  • Lovecek M; Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Parana, Brazil.
  • Cavestro GM; Oncology of Massa Carrara, Oncological Department, Azienda USL Toscana Nord Ovest, Carrara, Italy.
  • Milanetto AC; Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
  • Peduzzi G; Department of Surgery, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Duchonova BM; University Hospital Olomouc, Olomouc, Czech Republic.
  • Izbicki JR; Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Zalinkevicius R; Department of DiSCOG, University of Padova, Padua, Italy.
  • Hlavac V; Department of Biology, University of Pisa, Pisa, Italy.
  • van Eijck CHJ; Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic.
  • Brenner H; Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
  • Vanella G; Clinics of Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Vokacova K; Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Pilsen, Czech Republic.
  • Soucek P; Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  • Tavano F; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Perri F; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Capurso G; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Hussein T; Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy.
  • Kiudelis M; Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
  • Kupcinskas J; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
  • Busch OR; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Morelli L; Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Pilsen, Czech Republic.
  • Theodoropoulos GE; Division of Gastroenterology and Research Laboratory, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
  • Testoni SGG; Division of Gastroenterology and Research Laboratory, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
  • Adamonis K; Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy.
  • Neoptolemos JP; Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
  • Gazouli M; Center for Translational Medicine, Semmelweis University, Budapest, Hungary.
  • Pasquali C; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Int J Cancer ; 2024 Jun 26.
Article em En | MEDLINE | ID: mdl-38924078
ABSTRACT
Correlated regions of systemic interindividual variation (CoRSIV) represent a small proportion of the human genome showing DNA methylation patterns that are the same in all human tissues, are different among individuals, and are partially regulated by genetic variants in cis. In this study we aimed at investigating single-nucleotide polymorphisms (SNPs) within CoRSIVs and their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV-SNPs and 133,615 CoRSIV-mQTLs in 14,394 cases and 247,022 controls of European and Asian descent. We observed that the A allele of the rs2976395 SNP was associated with increased PDAC risk in Europeans (p = 2.81 × 10-5). This SNP lies in the prostate stem cell antigen gene and is in perfect linkage disequilibrium with a variant (rs2294008) that has been reported to be associated with risk of many other cancer types. The A allele is associated with the DNA methylation level of the gene according to the PanCan-meQTL database and with overexpression according to QTLbase. The expression of the gene has been observed to be deregulated in many tumors of the gastrointestinal tract including pancreatic cancer; however, functional studies are needed to elucidate the function relevance of the association.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Cancer Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Cancer Ano de publicação: 2024 Tipo de documento: Article