[Role of Telomere in Clonal Evolution of Acquired Aplastic Anemia--Review].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 32(3): 962-964, 2024 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-38926996
ABSTRACT
Studies have found that 1/3 patients with acquired aplastic anemia have shortened telomere length, and the shorter the telomere, the longer the disease course, the more prone to relapse, the lower the overall survival rate, and the higher the probability of clonal evolution. The regulation of telomere length is affected by many factors, including telomerase activity, telomerase-related genes, telomere regulatory proteins and other related factors. Telomere shortening can lead to genetic instability and increases the probability of clonal evolution in patients with acquired aplastic anemia. This article reviews the role of telomere in the clonal evolution of acquired aplastic anemia and factors affecting telomere length.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Homeostase do Telômero
/
Anemia Aplástica
Limite:
Humans
Idioma:
Zh
Revista:
Zhongguo Shi Yan Xue Ye Xue Za Zhi
Ano de publicação:
2024
Tipo de documento:
Article