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Chemical Characterization, Free Radical Scavenging, and Cellular Antioxidant Properties of the Egadi Island Endemic Brassica macrocarpa Guss Leaf Extract.
Cicio, Adele; Aloi, Noemi; Sut, Stefania; Longo, Valeria; Terracina, Francesca; Dall'Acqua, Stefano; Zizzo, Maria Grazia; Bruno, Maurizio; Ilardi, Vincenzo; Colombo, Paolo; Luparello, Claudio; Serio, Rosa.
Afiliação
  • Cicio A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Università degli Studi di Palermo, Viale delle Scienze, 90128 Palermo, Italy.
  • Aloi N; Institute for Biomedical Research and Innovation, National Research Council of Italy (IRIB-CNR), Via Ugo la Malfa 153, 90146 Palermo, Italy.
  • Sut S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
  • Longo V; Institute for Biomedical Research and Innovation, National Research Council of Italy (IRIB-CNR), Via Ugo la Malfa 153, 90146 Palermo, Italy.
  • Terracina F; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Università degli Studi di Palermo, Viale delle Scienze, 90128 Palermo, Italy.
  • Dall'Acqua S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
  • Zizzo MG; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Università degli Studi di Palermo, Viale delle Scienze, 90128 Palermo, Italy.
  • Bruno M; ATeN (Advanced Technologies Network) Center, Viale delle Scienze, University of Palermo, 90128 Palermo, Italy.
  • Ilardi V; NBFC-National Biodiversity Future Center, University of Palermo, 90133 Palermo, Italy.
  • Colombo P; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Università degli Studi di Palermo, Viale delle Scienze, 90128 Palermo, Italy.
  • Luparello C; NBFC-National Biodiversity Future Center, University of Palermo, 90133 Palermo, Italy.
  • Serio R; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Università degli Studi di Palermo, Viale delle Scienze, 90128 Palermo, Italy.
Biomolecules ; 14(6)2024 May 29.
Article em En | MEDLINE | ID: mdl-38927041
ABSTRACT
The genus Brassica is an important source of food in the Mediterranean diet with documented nutritional and medicinal properties. However, few studies have investigated the phytochemical composition and the biological activity of wild Sicilian taxa. Thus, we aimed to study the chemical profile and the antioxidant potential, in vitro and in LPS-stimulated RAW 264.7 cells, of a methanolic extract of leaves of wild Brassica macrocarpa Guss (B. macrocarpa) (Egadi Islands; Sicily-Italy). B. macrocarpa methanolic extract showed a large amount of glucosinolates and different phenolic compounds. It exhibited antioxidant activity in the DPPH assay and in LPS-stimulated RAW 264.7 cells, being able to reduce NO and ROS levels and NOS2 mRNA expression. Our study demonstrated that Sicilian B. macrocarpa methanolic extract, in LPS-stimulated macrophages, efficiently counteracts oxidative stress and displays radical scavenging activity. Future studies are required to identify the contribution of the single phytocomponents, to characterize the action mechanism, and to reveal possible applications in human health.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Brassica / Extratos Vegetais / Sequestradores de Radicais Livres / Folhas de Planta / Antioxidantes Limite: Animals País/Região como assunto: Europa Idioma: En Revista: Biomolecules Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Brassica / Extratos Vegetais / Sequestradores de Radicais Livres / Folhas de Planta / Antioxidantes Limite: Animals País/Região como assunto: Europa Idioma: En Revista: Biomolecules Ano de publicação: 2024 Tipo de documento: Article