[Effect of metabolic reprogramming on abdominal aortic aneurysm].
Sheng Li Xue Bao
; 76(3): 457-474, 2024 Jun 25.
Article
em Zh
| MEDLINE
| ID: mdl-38939940
ABSTRACT
Abdominal aortic aneurysm (AAA) is a life-threatening disease that remains undetected until it acutely ruptures. Due to lack of effective pharmaceutic therapies, it is urgent to explore new prevention and treatment strategies. Metabolic reprogramming is a cellular process through which cells change their metabolic patterns to meet material and energy requirements, including glucose metabolism, lipid metabolism and amino acid metabolism. Recently, the regulatory role of metabolic reprogramming in cardiovascular diseases, especially AAA, has attracted significant attention. This review article focuses on the research progress regarding the effects of metabolic reprogramming of vascular smooth muscle cells (VSMCs) and macrophages on the occurrence and development of AAA, especially their roles in major pathological processes such as VSMCs apoptosis and phenotype transformation, extracellular matrix remodeling, oxidative stress, and inflammatory response. The aim is to provide new clues for the mechanism research and clinical treatment of AAA from the perspective of metabolism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aneurisma da Aorta Abdominal
/
Músculo Liso Vascular
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Ano de publicação:
2024
Tipo de documento:
Article