Mediator complex in transcription regulation and DNA repair: Relevance for human diseases.
DNA Repair (Amst)
; 141: 103714, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38943827
ABSTRACT
The Mediator complex is an essential coregulator of RNA polymerase II transcription. More recent developments suggest Mediator functions as a link between transcription regulation, genome organisation and DNA repair mechanisms including nucleotide excision repair, base excision repair, and homologous recombination. Dysfunctions of these processes are frequently associated with human pathologies, and growing evidence shows Mediator involvement in cancers, neurological, metabolic and infectious diseases. The detailed deciphering of molecular mechanisms of Mediator functions, using interdisciplinary approaches in different biological models and considering all functions of this complex, will contribute to our understanding of relevant human diseases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Reparo do DNA
/
Complexo Mediador
Limite:
Animals
/
Humans
Idioma:
En
Revista:
DNA Repair (Amst)
Ano de publicação:
2024
Tipo de documento:
Article