Antitumor effect of nanophotothermolysis mediated by zinc phthalocyanine particles.
Nanomedicine
; 61: 102768, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-38945506
ABSTRACT
Nanophotothermolysis (NPhT) effect is considered to be an approach for the development of highly selective modalities for anticancer treatment. Herein, we evaluated an antitumor efficacy of NPhT with intravenously injected zinc phthalocyanine particles (ZnPcPs) in murine subcutaneous syngeneic tumor models. In S37 sarcoma-bearing mice a biodistribution of ZnPcPs was studied and the high antitumor efficacy of ZnPcPs-mediated NPhT was shown, including a response of metastatic lesions. The morphological investigation showed the main role of a local NPhT-induced vascular damage in the tumor growth and tumor spread inhibition. Murine tumors of different histological origin were not equally sensitive to the treatment. The results demonstrate a potential of ZnPcPs-mediated NPhT for treatment of surface tumors.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Compostos de Zinco
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Isoindóis
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Indóis
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Nanomedicine
Ano de publicação:
2024
Tipo de documento:
Article