Cerebral Aspects of Portal Hypertension: Hepatic Encephalopathy.
Clin Liver Dis
; 28(3): 541-554, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38945642
ABSTRACT
Portal hypertension has cerebral consequences via its causes and complications, namely hepatic encephalopathy (HE), a common and devastating brain disturbance caused by liver insufficiency and portosystemic shunting. The pathogenesis involves hyperammonemia and systemic inflammation. Symptoms are disturbed personality and reduced attention. HE is minimal or grades I to IV (coma). Bouts of HE are episodic and often recurrent. Initial treatment is of events that precipitated the episode and exclusion of nonhepatic causes. Specific anti-HE treatment is lactulose. By recurrence, rifaximin is add-on. Anti-HE treatment is efficacious also for prophylaxis, but emergence of HE marks advanced liver disease and a dismal prognosis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalopatia Hepática
/
Hipertensão Portal
/
Lactulose
Limite:
Humans
Idioma:
En
Revista:
Clin Liver Dis
Ano de publicação:
2024
Tipo de documento:
Article