An orphan to the rescue of obesity and steatotic liver?
Trends Endocrinol Metab
; 35(9): 761-762, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38945795
ABSTRACT
In a recent article, Leeson-Payne et al. demonstrate that GPR75 knock-out in mice results in lower body fat and reduced hepatic lipid accumulation, with an increase in physical activity and energy expenditure. Loss-of-function (LoF) GPR75 variants in the UK Biobank (UKBB) are associated with reduced liver steatosis, suggesting potential therapeutic implications in metabolic dysfunction-associated steatotic liver disease (MASLD).
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fígado Gorduroso
/
Obesidade
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Endocrinol Metab
Ano de publicação:
2024
Tipo de documento:
Article