The chemical biology of dinitrogen trioxide.
Redox Biochem Chem
; 82024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38957295
ABSTRACT
Dinitrogen trioxide ( N 2 O 3 ) mediates low-molecular weight and protein S- and N-nitrosation, with recent reports suggesting a role in the formation of nitrating intermediates as well as in nitrite-dependent hypoxic vasodilatation. However, the reactivity of N 2 O 3 in biological systems results in an extremely short half-life that renders this molecule essentially undetectable by currently available technologies. As a result, evidence for in vivo N 2 O 3 formation derives from the detection of nitrosated products as well as from in vitro kinetic determinations, isotopic labeling studies, and spectroscopic analyses. This review will discuss mechanisms of N 2 O 3 formation, reactivity and decomposition, as well as address the role of sub-cellular localization as a key determinant of its actions. Finally, evidence will be discussed supporting different roles for N 2 O 3 as a biologically relevant signaling molecule.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Redox Biochem Chem
Ano de publicação:
2024
Tipo de documento:
Article