Sex-dependent differences in macaque brain mitochondria.
Biochim Biophys Acta Bioenerg
; 1865(4): 149494, 2024 11 01.
Article
em En
| MEDLINE
| ID: mdl-38960079
ABSTRACT
Mitochondrial bioenergetics in females and males is different. However, whether mitochondria from male and female brains display differences in enzymes of oxidative phosphorylation remains unknown. Therefore, we characterized mitochondrial complexes from the brains of male and female macaques (Macaca mulatta). Cerebral tissue from male macaques exhibits elevated content and activity of mitochondrial complex I (NADHubiquinone oxidoreductase) and higher activity of complex II (succinate dehydrogenase) compared to females. No significant differences between sexes were found in the content of α-ketoglutarate dehydrogenase or in the activities of cytochrome c oxidase and F1Fo ATPase. Our results underscore the need for further investigations to elucidate sex-related mitochondrial differences in humans.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Mitocôndrias
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta Bioenerg
Ano de publicação:
2024
Tipo de documento:
Article