Effect of Hb conformational changes on oxygen transport physiology. / Hbæ象åå对氧转è¿ççåè½çå½±å.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 49(3): 467-475, 2024 Mar 28.
Article
em En, Zh
| MEDLINE
| ID: mdl-38970521
ABSTRACT
Red blood cells (RBCs) are the primary mediators of oxygen transport in the human body, and their function is mainly achieved through conformational changes of hemoglobin (Hb). Hb is a tetramer composed of four subunits, with HbA being the predominant Hb in healthy adults, existing in two forms tense state (T state) and relaxed state (R state). Endogenous regulators of Hb conformation include 2,3-diphosphoglyceric acid, carbon dioxide, protons, and chloride ions, while exogenous regulators include inositol hexaphosphate, inositol tripyrophosphate, benzabate, urea derivative L35, and vanillin, each with different mechanisms of action. The application of Hb conformational regulators provides new insights into the study of hypoxia oxygen supply issues and the treatment of sickle cell disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Conformação Proteica
/
Hemoglobinas
Limite:
Humans
Idioma:
En
/
Zh
Revista:
Zhong Nan Da Xue Xue Bao Yi Xue Ban
Ano de publicação:
2024
Tipo de documento:
Article