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The causality between leisure sedentary behaviors, physical activity and obstructive sleep apnea: a bidirectional Mendelian randomization study.
Tian, Haonan; Wang, Aozhe; Wu, Han; Zhou, Cailiang; Zhang, Zhenglong; Wang, Jun.
Afiliação
  • Tian H; Department of Exercise Physiology, Beijing Sport University, Beijing, China.
  • Wang A; Department of Exercise Physiology, Beijing Sport University, Beijing, China.
  • Wu H; Department of Exercise Physiology, Beijing Sport University, Beijing, China.
  • Zhou C; Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, China.
  • Zhang Z; Department of Graduate School, Harbin Sport University, Harbin, China.
  • Wang J; Department of Exercise Physiology, Beijing Sport University, Beijing, China.
Front Public Health ; 12: 1425060, 2024.
Article em En | MEDLINE | ID: mdl-38975351
ABSTRACT

Background:

Previous observational studies have shown a correlation between leisure sedentary behaviors (LSB) and physical activity (PA) with the incidence of obstructive sleep apnea (OSA). However, the causal associations remain unknown. Therefore, our study used bidirectional two-sample Mendelian randomization (MR) to identify potential causal relationships between LSB/PA and OSA.

Methods:

We sourced genetic variation data for LSB and PA from the UK Biobank, while data on OSA were collected from the FinnGen study. The primary analysis method employed was the inverse variance weighted (IVW) approach, complemented by the weighted median and MR-Egger methods. For sensitivity analyses, we conducted Cochran's Q test, the MR-Egger intercept test, the MR-PRESSO global test, and the leave-one-out analysis.

Results:

IVW analyses showed that genetically predicted leisure television watching (odds ratio [OR] = 1.38, 95% confidence interval [CI] = 1.09-1.75, p = 0.007) and computer use (OR = 1.48, 95% CI = 1.15-1.92, p = 0.002) significantly increased the risk of OSA. Conversely, self-reported vigorous physical activity (VPA) (OR = 0.33, 95% CI = 0.11-0.98, p = 0.046) may reduce the risk of OSA. No causal effects on OSA risk were observed for driving or self-reported moderate-to-vigorous physical activity. Furthermore, the reverse MR analysis indicated no significant causal relationship between OSA and any LSB/PA phenotype. Sensitivity tests showed no significant heterogeneity or horizontal pleiotropy.

Conclusion:

This study suggests that leisurely television watching and computer use are risk factors for OSA, while VPA may be a protective factor. Additionally, OSA does not affect PA or LSB levels. We recommend reducing sedentary activities, particularly television watching and computer use, and prioritizing VPA to reduce the risk of OSA. Further research in diverse populations and settings is needed to validate these findings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Apneia Obstrutiva do Sono / Análise da Randomização Mendeliana / Comportamento Sedentário / Atividades de Lazer Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Front Public Health Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exercício Físico / Apneia Obstrutiva do Sono / Análise da Randomização Mendeliana / Comportamento Sedentário / Atividades de Lazer Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Front Public Health Ano de publicação: 2024 Tipo de documento: Article