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Evaluation of quercetin as a potential cytoprotector against acetaldehyde using the cultured hepatocyte model with aldehyde dehydrogenase isozyme deficiency.
Xu, Yuhang; Sawamoto, Takeshi; Sun, Ruitong; Ishikura, Aki; Munemasa, Shintaro; Murata, Yoshiyuki; Satoh, Ayano; Matsumoto, Akiko; Nakamura, Toshiyuki; Nakamura, Yoshimasa.
Afiliação
  • Xu Y; G raduate School of Environmental and Life Science, Okayama University, Okayama, Japan.
  • Sawamoto T; School of Food Science and Technology, Dalian Polytechnic University, Dalian Liaoning, China.
  • Sun R; Graduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama, Japan.
  • Ishikura A; G raduate School of Environmental and Life Science, Okayama University, Okayama, Japan.
  • Munemasa S; School of Food Science and Technology, Dalian Polytechnic University, Dalian Liaoning, China.
  • Murata Y; G raduate School of Environmental and Life Science, Okayama University, Okayama, Japan.
  • Satoh A; G raduate School of Environmental and Life Science, Okayama University, Okayama, Japan.
  • Matsumoto A; Graduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama, Japan.
  • Nakamura T; G raduate School of Environmental and Life Science, Okayama University, Okayama, Japan.
  • Nakamura Y; Graduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama, Japan.
Biosci Biotechnol Biochem ; 88(10): 1199-1202, 2024 Sep 20.
Article em En | MEDLINE | ID: mdl-38991992
ABSTRACT
Protective effect of quercetin against acetaldehyde was evaluated using the cultured hepatocyte models with aldehyde dehydrogenase (ALDH) isozyme deficiency (aldh2-kd and aldh1a1-kd). The quercetin-induced cytoprotection against acetaldehyde in the ALDH1A1-deficient mutant (aldh1a1-kd) was weaker than that in the wild type. Furthermore, quercetin did not enhance the ALDH activity in aldh1a1-kd cells, suggesting that ALDH1A1 is involved in quercetin-induced cytoprotection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quercetina / Hepatócitos / Aldeído Desidrogenase / Isoenzimas / Acetaldeído Limite: Animals Idioma: En Revista: Biosci Biotechnol Biochem Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quercetina / Hepatócitos / Aldeído Desidrogenase / Isoenzimas / Acetaldeído Limite: Animals Idioma: En Revista: Biosci Biotechnol Biochem Ano de publicação: 2024 Tipo de documento: Article