Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease.
Aging Cell
; 23(10): e14260, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-38994634
ABSTRACT
Amyloid plaques, a major pathological hallmark of Alzheimer's disease (AD), are caused by an imbalance between the amyloidogenic and non-amyloidogenic pathways of amyloid precursor protein (APP). BACE1 cleavage of APP is the rate-limiting step for amyloid-ß production and plaque formation in AD. Although the alteration of BACE1 expression in AD has been investigated, the underlying mechanisms remain unknown. In this study, we determined MEIS2 was notably elevated in AD models and AD patients. Alterations in the expression of MEIS2 can modulate the levels of BACE1. MEIS2 downregulation improved the learning and memory retention of AD mice and decreased the number of amyloid plaques. MEIS2 binds to the BACE1 promoter, positively regulates BACE1 expression, and accelerates APP amyloid degradation in vitro. Therefore, our findings suggest that MEIS2 might be a critical transcription factor in AD, since it regulates BACE1 expression and accelerates BACE1-mediated APP amyloidogenic cleavage. MEIS2 is a promising early intervention target for AD treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Ácido Aspártico Endopeptidases
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Proteínas de Homeodomínio
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Progressão da Doença
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Secretases da Proteína Precursora do Amiloide
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Doença de Alzheimer
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Aging Cell
Ano de publicação:
2024
Tipo de documento:
Article