Cellular senescence in metastatic prostate cancer: A therapeutic opportunity or challenge (Review).
Mol Med Rep
; 30(3)2024 09.
Article
em En
| MEDLINE
| ID: mdl-38994760
ABSTRACT
The treatment of patients with metastatic prostate cancer (PCa) is considered to be a longstanding challenge. Conventional treatments for metastatic PCa, such as radical prostatectomy, radiotherapy and androgen receptortargeted therapy, induce senescence of PCa cells to a certain extent. While senescent cells can impede tumor growth through the restriction of cell proliferation and increasing immune clearance, the senescent microenvironment may concurrently stimulate the secretion of a senescenceassociated secretory phenotype and diminish immune cell function, which promotes PCa recurrence and metastasis. Resistance to established therapies is the primary obstacle in treating metastatic PCa as it can lead to progression towards an incurable state of disease. Therefore, understanding the molecular mechanisms that underly the progression of PCa is crucial for the development of novel therapeutic approaches. The present study reviews the phenomenon of treatmentinduced senescence in PCa, the dual role of senescence in PCa treatments and the mechanisms through which senescence promotes PCa metastasis. Furthermore, the present review discusses potential therapeutic strategies to target the aforementioned processes with the aim of providing insights into the evolving therapeutic landscape for the treatment of metastatic PCa.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Senescência Celular
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Microambiente Tumoral
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Metástase Neoplásica
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Mol Med Rep
Ano de publicação:
2024
Tipo de documento:
Article