Clinical outcome assessment of colistin sulphate in children with carbapenem-resistant organism infections: First data from China.
Int J Antimicrob Agents
; 64(3): 107273, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39002699
ABSTRACT
OBJECTIVES:
Colistin sulphate for injection (CSI) became clinically available in China in July 2019. To date, there is no published data regarding its usage in children. Our research group has been following data on the efficacy and safety of CSI in Chinese paediatric patients with carbapenem-resistant organism infections. The purpose of this short communication is to provide a brief overview of the findings to date.METHODS:
We reviewed the electronic medical records of paediatric patients (aged 9-17 y) who were administered CSI during their hospital stay at Tongji Hospital in Wuhan, China, between June 2021 and November 2023. Drug efficacy was evaluated based on clinical and microbiological outcomes, while drug safety was assessed using surveillance markers that reflect adverse reactions.RESULTS:
A total of 20 patients met the inclusion criteria. The predominant pathogens were Klebsiella pneumoniae (8 strains), followed by Acinetobacter baumannii (5 strains) and Pseudomonas aeruginosa (2 strains). The clinical response rate of CSI was 85%, with a bacterial clearance rate of 79%. None of the patients experienced colistin-related nephrotoxicity or neurotoxicity during the treatment.CONCLUSIONS:
In this real-world setting, CSI demonstrated a high level of clinical response and was well tolerated for the treatment of carbapenem-resistant organism infections in Chinese children.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
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Carbapenêmicos
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Colistina
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Klebsiella pneumoniae
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Antibacterianos
Limite:
Adolescent
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Child
/
Female
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Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Int J Antimicrob Agents
Ano de publicação:
2024
Tipo de documento:
Article