Virus as the cause of type 1 diabetes.
Trends Mol Med
; 2024 Jul 13.
Article
em En
| MEDLINE
| ID: mdl-39003200
ABSTRACT
Type 1 diabetes (T1D), a severe disease requiring intensive insulin treatment, carries an increased risk for complications and reduced lifespan. Certain viruses have been implicated in T1D's etiology, with 'live', replicating enteroviruses (EVs) recently found in the pancreas at diagnosis. This discovery prompted a trial to slow down disease progression using antiviral drugs. A 6-month treatment combining pleconaril and ribavirin in new-onset T1D patients preserved residual insulin production after 1 year, unlike placebo. The results support the theory that viruses may cause T1D in genetically susceptible individuals. A low-grade, persistent viral infection may initiate a cascade of pathogenic mechanisms initially involving the innate immune system, inducing ß-cell stress and neoantigen release, leading to autoimmunity, and eventually the destruction of insulin-producing ß-cells.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Trends Mol Med
Ano de publicação:
2024
Tipo de documento:
Article