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High-throughput label-free opioid receptor binding assays using an automated desorption electrospray ionization mass spectrometry platform.
Feng, Yunfei; Morato, Nicolás M; Huang, Kai-Hung; Lin, Mina; Cooks, R Graham.
Afiliação
  • Feng Y; Department of Chemistry, Bindley Bioscience Center, and Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. cooks@purdue.edu.
  • Morato NM; Department of Chemistry, Bindley Bioscience Center, and Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. cooks@purdue.edu.
  • Huang KH; Department of Chemistry, Bindley Bioscience Center, and Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. cooks@purdue.edu.
  • Lin M; Department of Chemistry, Bindley Bioscience Center, and Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. cooks@purdue.edu.
  • Cooks RG; Department of Chemistry, Bindley Bioscience Center, and Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. cooks@purdue.edu.
Chem Commun (Camb) ; 60(63): 8224-8227, 2024 Aug 01.
Article em En | MEDLINE | ID: mdl-39007214
ABSTRACT
The current opioid epidemic has incentivized the discovery of new non-addictive analgesics, a process that requires the screening of opioid receptor binding, traditionally performed using radiometric assays. Here we describe a label-free alternative based on high-throughput (1 Hz) ambient mass spectrometry for screening the receptor binding of new opioid analogues.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Opioides / Espectrometria de Massas por Ionização por Electrospray / Ensaios de Triagem em Larga Escala Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Opioides / Espectrometria de Massas por Ionização por Electrospray / Ensaios de Triagem em Larga Escala Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2024 Tipo de documento: Article