[Immunomodulation in the tumor microenvironment: Therapeutic potential of combined inhibition of tumor hypoxia and PD-1/ PD-L1]. / Immunmoduláció a tumor mikrokörnyezetében: a tumorhipoxia és a PD-1/PD-L1 együttes gátlásának terápiás lehetoségei.
Magy Onkol
; 68(2): 126-135, 2024 Jul 16.
Article
em Hu
| MEDLINE
| ID: mdl-39013086
ABSTRACT
Tumor hypoxia plays an important role in controlling tumor progression through signaling pathways related to the transcription factor HIF-1. In addition to enhancing migration, promoting angiogenesis and regulating metabolism, the hypoxic environment also affects immune function. In this hypoxic microenvironment an immunosuppressive milieu is established, where HIF-1 upregulates the expression of PD-L1, a key regulator of the immune response. We have found that elevated expression of PD-L1 correlates with increased HIF-1 levels in cancer cell lines and clinical samples. Thus, the co-inhibition of HIF-1 and PD-1/PD-L1 offers promising therapeutic possibilities. In this review we have examined the limitations of HIF-1 and PD-1/PD-L1 inhibition as monotherapy, explored their combined benefits and evaluated the feasibility of targeting PD-L1 with HIF-1 inhibitors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microambiente Tumoral
/
Antígeno B7-H1
/
Receptor de Morte Celular Programada 1
/
Hipóxia Tumoral
/
Neoplasias
Limite:
Humans
Idioma:
Hu
Revista:
Magy Onkol
Ano de publicação:
2024
Tipo de documento:
Article