In silico approaches for better understanding cysteine cathepsin-glycosaminoglycan interactions.
Carbohydr Res
; 543: 109201, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39013335
ABSTRACT
Cysteine cathepsins constitute the largest cathepsin family, with 11 proteases in human that are present primarily within acidic endosomal and lysosomal compartments. They are involved in the turnover of intracellular and extracellular proteins. They are synthesized as inactive procathepsins that are converted to mature active forms. Cathepsins play important roles in physiological and pathological processes and, therefore, receive increasing attention as potential therapeutic targets. Their maturation and activity can be regulated by glycosaminoglycans (GAGs), long linear negatively charged polysaccharides composed of recurring dimeric units. In this review, we summarize recent computational progress in the field of (pro)cathepsin-GAG complexes analyses.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Catepsinas
/
Glicosaminoglicanos
Limite:
Humans
Idioma:
En
Revista:
Carbohydr Res
Ano de publicação:
2024
Tipo de documento:
Article