Trace elements in pancreatic cancer.
Cancer Med
; 13(14): e7454, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-39015024
ABSTRACT
BACKGROUND:
Pancreatic cancer (PCA) is an extremely aggressive malignant cancer with an increasing incidence and a low five-year survival rate. The main reason for this high mortality is that most patients are diagnosed with PCA at an advanced stage, missing early treatment options and opportunities. As important nutrients of the human body, trace elements play an important role in maintaining normal physiological functions. Moreover, trace elements are closely related to many diseases, including PCA. REVIEW This review systematically summarizes the latest research progress on selenium, copper, arsenic, and manganese in PCA, elucidates their application in PCA, and provides a new reference for the prevention, diagnosis and treatment of PCA.CONCLUSION:
Trace elements such as selenium, copper, arsenic and manganese are playing an important role in the risk, pathogenesis, diagnosis and treatment of PCA. Meanwhile, they have a certain inhibitory effect on PCA, the mechanism mainly includes promoting ferroptosis, inducing apoptosis, inhibiting metastasis, and inhibiting excessive proliferation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
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Arsênio
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Selênio
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Oligoelementos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Med
Ano de publicação:
2024
Tipo de documento:
Article