Biomarker of severity in hospitalised patients with COVID-19: a retrospective study.
BMJ Open
; 14(7): e081627, 2024 Jul 17.
Article
em En
| MEDLINE
| ID: mdl-39019644
ABSTRACT
BACKGROUND:
The novel COVID-19 was rapidly spreading and was highly contagious. COVID-19 caused over 6 million deaths worldwide, with high mortality rates, particularly in severe cases.OBJECTIVE:
This study aimed to investigate whether serum albumin-neutrophil count to lymphocyte count ratio (NLR) score (ANS) could be used as a prognostic indicator of COVID-19 severity.DESIGN:
A retrospective study.PARTICIPANTS:
Based on the WHO diagnostic criteria, patients were classified as either non-severe (n=270) or severe (n=100). PRIMARY AND SECONDARY OUTCOMEMEASURES:
NLR, serum albumin level and ANS. MAINRESULTS:
The NLR of patients with severe disease was significantly higher than that of those with non-severe disease. Serum albumin levels were significantly lower in patients with severe disease than in those with non-severe disease. The cut-off values representing the maximum potential effectiveness of serum albumin and NLR were 33.5 g/L and 8.25, respectively, according to the Youden index. In patients with severe COVID-19, we observed that the serum albumin level, NLR and ANS were independent prognostic indicators of severe COVID-19 using logistic analysis. The relative risk of severe COVID-19 was 7.65 (95% CI 3.72 to 15.75, p<0.05) in the ANS 2 group compared with that in ANS 0.CONCLUSIONS:
ANS could be used as a prognostic indicator of COVID-19 severity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
/
Albumina Sérica
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Biomarcadores
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SARS-CoV-2
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COVID-19
/
Neutrófilos
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
BMJ Open
Ano de publicação:
2024
Tipo de documento:
Article