Endothelial and macrophage interactions in the angiogenic niche.
Cytokine Growth Factor Rev
; 78: 64-76, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-39019663
ABSTRACT
The interactions between vascular cells, especially endothelial cells, and macrophages play a pivotal role in maintaining the subtle balance of vascular biology, which is crucial for angiogenesis in both healthy and diseased states. These cells are central to ensuring a harmonious balance between tissue repair and preventing excessive angiogenic activity, which could lead to pathological conditions. Recent advances in sophisticated genetic engineering vivo models and novel sequencing approaches, such as single-cell RNA-sequencing, in immunobiology have significantly enhanced our understanding of the gene expression and behavior of macrophages. These insights offer new perspectives on the role macrophages play not only in development but also across various health conditions. In this review, we explore the complex interactions between multiple types of macrophages and endothelium, focusing on their impact on new blood vessel formation. By understanding these intricate interactions, we aim to provide insights into new methods for managing angiogenesis in various diseases, thereby offering hope for the development of novel therapeutic approaches.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neovascularização Fisiológica
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Células Endoteliais
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Macrófagos
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Neovascularização Patológica
Limite:
Animals
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Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Ano de publicação:
2024
Tipo de documento:
Article