Wajeepeptin, a Cytotoxic and Antitrypanosomal Cyclic Depsipeptide from a Marine <i>Moorena</i> sp. Cyanobacterium.

Kurisawa, Naoaki; Jeelani, Ghulam; Nozaki, Tomoyoshi; Agusta, Adnan Luthfi; Suenaga, Kiyotake; Iwasaki, Arihiro

Wajeepeptin, a Cytotoxic and Antitrypanosomal Cyclic Depsipeptide from a Marine Moorena sp. Cyanobacterium.

Kurisawa, Naoaki; Jeelani, Ghulam; Nozaki, Tomoyoshi; Agusta, Adnan Luthfi; Suenaga, Kiyotake; Iwasaki, Arihiro.

Afiliação

Kurisawa N; Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Jeelani G; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Agusta AL; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Suenaga K; Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Iwasaki A; Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.

J Nat Prod ; 87(7): 1838-1843, 2024 Jul 26.

Article em En | MEDLINE | ID: mdl-39021085

ABSTRACT

ABSTRACT

Here, we report wajeepeptin (1), a new cyclic depsipeptide isolated from a marine Moorena sp. cyanobacterium. The structure was elucidated by a combination of spectroscopic analyses, X-ray diffraction analysis, and degradation reactions. Wajeepeptin (1) showed moderate cytotoxicity (IC50 = 3.7 µM against HeLa cells) and potent antitrypanosomal activity (IC50 = 0.73 ± 0.14 µM against Trypanosoma brucei rhodesiense).

Assuntos

Cianobactérias; Depsipeptídeos; Depsipeptídeos/farmacologia; Depsipeptídeos/química; Depsipeptídeos/isolamento & purificação; Humanos; Estrutura Molecular; Células HeLa; Cianobactérias/química; Trypanosoma brucei rhodesiense/efeitos dos fármacos; Biologia Marinha; Tripanossomicidas/farmacologia; Tripanossomicidas/química; Ensaios de Seleção de Medicamentos Antitumorais; Cristalografia por Raios X; Ressonância Magnética Nuclear Biomolecular

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cianobactérias / Depsipeptídeos Limite: Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2024 Tipo de documento: Article

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