Non-vitamin K oral antagonist (NOAC) compared to vitamin K antagonist (VKA) in left ventricular thrombus.
J Family Med Prim Care
; 13(6): 2485-2490, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-39027879
ABSTRACT
Background:
Thromboembolic events are serious left ventricular thrombus (LVT) complications. Despite the limitations of vitamin K antagonist (VKA) drugs, it continues to be the recommended oral anticoagulation for LVT. Recently, nonvitamin K oral antagonist (NOAC) has gained popularity as an off-labeled treatment for systemic embolism prevention in LVT.Objective:
In this study, we aim to compare the outcomes (stroke and bleeding) of warfarin versus NOAC therapy in patients with LVT.Methods:
This retrospective cohort study compares NOAC and VKA therapy in LVT patients. We enrolled 201 patients with an echocardiography-confirmed LVT from January 2018 to December 2022. Patients who received NOAC therapy (NOAC, n = 77) were compared to VKA patients (VKA, n = 124). The primary endpoint was a composite of stroke, minor and major bleeding.Results:
The median follow-up time was 17 months (25th-75th percentiles 8-38). On unmatched analysis, both groups had no difference in major bleeding (log-rank, P = 0.61) and stroke (log-rank, P = 0.77). However, all bleeding events were higher with NOAC (log-rank, P = 0.01). On matched analysis, there was no difference between both groups in the overall bleeding events (P = 0.08), major bleeding (P = 0.57), and stroke (P = 0.66). Minor bleeding was significantly lower in the VKA group (P = 0.04).Conclusion:
In patients with LVT, NOAC was as effective as VKA in stroke prevention without increasing the risk of major bleeding.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Family Med Prim Care
Ano de publicação:
2024
Tipo de documento:
Article